Bilateral exophthalmos and lymphoblastic aleukaemic leukaemia.

Distinction between aleukaemic prodrome of childhood acute lymphoblastic leukaemia and aplastic anaemia.

AIMS To document the features of the so-called aplastic presentation of childhood acute lymphoblastic leukaemia (ALL) and to determine whether this prodrome can be distinguished from aplasia. METHODS The peripheral blood and bone marrow appearances of all cases of childhood ALL presenting in one health region of England in 13 years and eight months were reviewed. All cases presenting with cyt...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Severe exophthalmos secondary to orbital myopathy not due to Graves's disease.

An 18-month-old white female child presented with severe bilateral exophthalmos. She was thought to have Grave's disease because her orbital CT scan showed massively enlarge extraocular muscles. She was subsequently found to have myelomonocytic leukaemia. This was treated with radiation, with rapid resolution of her exophthalmos and exposure keratitis.

Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India

Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL...

Bilateral serous macular detachment as a presenting feature of acute lymphoblastic leukemia.

PURPOSE To report a case of bilateral serous maculopathy as an initial sign of acute lymphoblastic leukaemia in children. METHODS/RESULTS A 13-year-old girl, who presented with symptoms of visual blurring, was found to have a bilateral serous maculopathy. Haematological abnormalities (thrombocytopenia with a mild lymphocytosis) prompted further investigation. A bone marrow aspirate revealed t...